The Monaco 100-footer was overtaken briefly on Monday evening in Bass Strait by Sydney-based boat LawConnect but by 6.30am on Tuesday morning it had regained a six-nautical mile advantage.
New South Wales-based No Limit was forced to quit the race after a crew member suffered a broken arm.
Other boats have reported a range of problems, including hull damage, electrical and engine issues and damage to rudders and sails.
The Tasmanian boat Sidewinder is leading the new two-handed sailing category ahead of 10 others.
